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A Biofriendly Silica Gel for in Situ Protein Entrapment: Biopolymer-Assisted Formation and Its Kinetic Mechanism.
- Source :
-
Journal of Physical Chemistry B . Mar2009, Vol. 113 Issue 9, p2688-2694. 7p. - Publication Year :
- 2009
-
Abstract
- In an attempt to develop a biofriendly sol−gel route for the rapid formation of biofunctional silica gels, a biopolymer with good biocompatibility was used to assist the gelation of glycol-modified tetraethoxysilane (GMT) in aqueous system without the addition of any organic solvents. It was found that the biopolymer used could act as an effective accelerator for the sol−gel transition of GMT and an increase of its amount could shorten greatly the gelation time. For such a gelation reaction, its apparent activation energy was determined to be 64.9 kJ/mol according to the Arrhenius equation. In particular, the kinetic mechanism for the formation of the silica gel was investigated by using dynamic rheological data and a scaling fractal model. It was revealed that the biopolymer used could change the sol−gel transition mechanism from reaction-limited kinetics to diffusion-limited kinetics. Circular dichroism analyses confirmed the suitability of using the resultant silica gel for the in situ protein encapsulation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15206106
- Volume :
- 113
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Physical Chemistry B
- Publication Type :
- Academic Journal
- Accession number :
- 36650965
- Full Text :
- https://doi.org/10.1021/jp810736v