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Synthesis, double stranded DNA-binding and photocleavage studies of a functionalized ruthenium(II) complex with 7,7′-methylenedioxyphenyldipyrido[3,2-a:2′,3′-c]-phenazine
- Source :
-
Journal of Inorganic Biochemistry . Mar2009, Vol. 103 Issue 3, p441-447. 7p. - Publication Year :
- 2009
-
Abstract
- Abstract: A new Ru(II) complex [Ru(phen)2(mdpz)]2+ (phen=1,10-phenanthroline, mdpz=7,7′-methylenedioxyphenyl-dipyrido-[3,2-a:2′,3′-c]phenazine) has been synthesized and characterized in detail by elemental analysis, mass spectrometry and 1H NMR spectroscopy. The interaction of the complex with calf thymus DNA was investigated by spectroscopic and viscosity measurements. The results suggest that the complex binds to DNA via an intercalative mode and serves as a molecular “light switch” for DNA. Moreover, the complex has been found to promote the photocleavage of plasmid DNA pBR322 under irradiation at 365nm. The mechanism studies reveal that singlet oxygen (1O2) plays a significant role in the photocleavage. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01620134
- Volume :
- 103
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Inorganic Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 36475314
- Full Text :
- https://doi.org/10.1016/j.jinorgbio.2008.12.010