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Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma
- Source :
-
Cancer Cell . Feb2009, Vol. 15 Issue 2, p135-147. 13p. - Publication Year :
- 2009
-
Abstract
- Summary: The growth of many cancers depends on self-renewing cells called cancer stem cells or tumor-propagating cells (TPCs). In human brain tumors, cells expressing the stem cell marker CD133 have been implicated as TPCs. Here we show that tumors from a model of medulloblastoma, the Patched mutant mouse, are propagated not by CD133+ cells but by cells expressing the progenitor markers Math1 and CD15/SSEA-1. These cells have a distinct expression profile that suggests increased proliferative capacity and decreased tendency to undergo apoptosis and differentiation. CD15 is also found in a subset of human medulloblastomas, and tumors expressing genes similar to those found in murine CD15+ cells have a poorer prognosis. Thus, CD15 may represent an important marker for TPCs in medulloblastoma. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 15356108
- Volume :
- 15
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Cell
- Publication Type :
- Academic Journal
- Accession number :
- 36339275
- Full Text :
- https://doi.org/10.1016/j.ccr.2008.12.016