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Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection.
- Source :
-
Journal of Cancer Research & Clinical Oncology . Mar2009, Vol. 135 Issue 3, p439-449. 11p. 1 Color Photograph, 4 Charts, 1 Graph. - Publication Year :
- 2009
-
Abstract
- To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (TM), in hepatocellular carcinoma (HCC) patients following resection. The infiltration of TAM and TM was assessed by immunohistochemistry in tissue microarray containing 302 HCC specimens. Correlations between TAM/TM infiltration and clinicopathologic features, disease-free survival (DFS) and overall survival (OS) were statistically analyzed. High TAM infiltration was associated with both improved DFS ( P = 0.0021) and OS ( P = 0.0481). Multivariate analysis identified TAM infiltration as independent prognostic factor for DFS ( P = 0.004) and OS ( P = 0.049). A second analysis clarified the synergistic effect of TAM&TM infiltration for DFS ( P = 0.004) and OS ( P = 0.040). Both TAM infiltration alone and concomitant infiltration of TAM&TM are associated with improved DFS/OS, suggesting that TAM could protect HCC patients from recurrence/metastasis and prolong survival by distinct mechanisms. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIVER cancer
*T cells
*IMMUNOHISTOCHEMISTRY
*CANCER patients
*METASTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 01715216
- Volume :
- 135
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Cancer Research & Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 36327369
- Full Text :
- https://doi.org/10.1007/s00432-008-0469-0