Synergic asymmetric organocatalysis (SAOc) of Cinchonaalkaloids and secondary amines in the synthesis of bicyclo[2.2.2]octan-2-onesThe authors wish to dedicate this paper to Professor Giovanni Piancatelli on the occasion of his 71st birthday.Electronic supplementary information (ESI) available: Characterization of new compounds and crystallographic data for 6a. CCDC 701756. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/b816550e

A synergistic effect between chiral secondary and tertiary amines gives access to bicyclo[2.2.2]octan-2-ones with up to 90% ee and >10 : 1 dr. [ABSTRACT FROM AUTHOR]