Indium/copper-mediated conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds in water

Authors :: Shen, Zhi-Liang
Cheong, Hao-Lun
Loh, Teck-Peng
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Mar2009, Vol. 50 Issue 9, p1051-1054. 4p.
Publication Year :: 2009
Abstract: Abstract: An efficient method for the conjugate addition of unactivated alkyl iodides to α,β-unsaturated carbonyl compounds using indium/copper in water is described. The reactions proceed more efficiently in water than in organic solvents. In, CuI, and InCl3 are all essential for efficient reaction. Formation of a symmetrical vic-diarylalkane is observed when an aryl-substituted alkene is used as substrate. [Copyright &y& Elsevier]

Subjects :: *ORGANIC synthesis
*IODIDES
*ADDITION reactions
*SOLUTION (Chemistry)
*ORGANIC solvents
*CARBONYL compounds

Language :: English
ISSN :: 00404039
Volume :: 50
Issue :: 9
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 36103087
Full Text :: https://doi.org/10.1016/j.tetlet.2008.12.079

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