Les entités anatomocliniques des CAPI relevant d’une prise en charge spécifique.

Carcinoma of unknown primary (CUP) origin is a quite heterogeneous entity with a poor prognosis. It accounts for about 5% of all neoplasms. CUP is defined as a histologically confirmed diagnosis of malignancy in patients with unremarkable medical history, normal physical examination and routine blood tests, and normal computed tomography. Among CUPs, several subsets have been identified as likely to be associated with a better life expectancy after specific treatment. About 15% of CUPs correspond to those specific subtypes: metastatic disease of lymph nodes such as nodal midline distribution, isolated metastases to axillary nodes, cervical involvement with squamous histology or inguinal nodal involvement; peritoneal papillary serous carcinomatosis in women; metastatic neuroendocrine carcinoma; osteoblastic bone metastases with elevated PSA in men; a single metastatic site. Thus, ruling out the primary and recognizing one of these subsets appear necessary in the management of patients with CUP tumours. [ABSTRACT FROM AUTHOR]