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Phase One Pilot Study Using Magnetic Resonance Spectroscopy to Predict the Histology of Radiofrequency-Ablated Renal Tissue
- Source :
-
European Urology . Feb2009, Vol. 55 Issue 2, p433-440. 8p. - Publication Year :
- 2009
-
Abstract
- Abstract: Introduction and Objective: Recent advances in magnetic resonance (MR) technology have allowed for high-resolution ex vivo spectroscopy on small, intact tissue samples. We examined the capability of 1H magnetic resonance magic angle spinning (MR-MAS) to correctly characterize post–radiofrequency ablation (RFA) renal biopsies from human samples, compared with standard histology and cross-sectional imaging. Methods: A minimum of two, 18G, percutaneous renal biopsies were obtained from ten biopsy-confirmed renal tumors at a mean 26.6 mo (range, 15–48) post-RFA. All patients were considered free of disease by computed tomography criteria. A portion of each sample was immediately frozen at −80°C for spectroscopy and the remainder used for pathological analysis. 1H MR-MAS was performed blinded with a 14.1-tesla field strength. Prior renal biopsies from nonablated tissue were used as positive controls for the spectral analysis. Concordance between, computed tomography, histology, and MR-MAS was analyzed. All spectroscopy was processed with VNMR software. Results: Histological analysis of all ten post-RFA biopsies demonstrated no cancer or viable tissue. All MR-MAS spectral peaks for each biopsy were consistent with necrosis and, more importantly, indicated an absence of small molecule metabolites characteristic of both normal and malignant renal tissue. Both MR-MAS and histology confirmed, in each case, the conventional computed tomography determination of complete ablation. Conclusions: MR spectroscopy can correctly diagnose the molecular absence of disease in post-RFA tissue biopsies. This proof of principle study warrants in vivo evaluation to confirm the clinical correlates of this modality. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03022838
- Volume :
- 55
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- European Urology
- Publication Type :
- Academic Journal
- Accession number :
- 35770663
- Full Text :
- https://doi.org/10.1016/j.eururo.2008.03.106