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Identification of Oral Cancer Cell-Induced Changes in Gene Expression Profile of Lymphatic Endothelial Cell.
- Source :
-
Cancer Investigation . Dec2008, Vol. 26 Issue 10, p1002-1007. 6p. 4 Charts. - Publication Year :
- 2008
-
Abstract
- Understading functional properties of tumor-derived lymphatic endothelial cells (TLEC) are relevant for blocking lymphatic metastasis. The changes of lymphatic endothelial cells (LEC) cocultured with oral cancer cells in a vitro model were examined. TLEC, in contrast to LEC, were more proliferative and have enhanced ability of lymphangiogenesis and anti-apoptosis. Gene microarrays revealed that 677 unique genes had two-fold or higher change between the two groups. Differential expressions of selected genes were confirmed by real-time PCR. Our results indicate that TLEC display abnormal characteristics and are distinct at the molecular level. Manipulation of TLEC is encouraging for therapy of lymphatic metastasis. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ORAL cancer
*CANCER cells
*METASTASIS
*CANCER invasiveness
*LYMPHATIC metastasis
Subjects
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 26
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 35753189
- Full Text :
- https://doi.org/10.1080/07357900802087234