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SHORT COMMUNICATION: Levodopa Therapy in Incomplete Spinal Cord Injury.
- Source :
-
Journal of Neurotrauma . Nov2008, Vol. 25 Issue 11, p1303-1307. 5p. - Publication Year :
- 2008
-
Abstract
- AbstractWe studied the influence of levodopa (L-Dopa) on training effects in subjects with spinal cord injury (SCI). A low-dose of L-Dopa per day is known to enhance the effects of physical training after stroke. This is tested here in subjects suffering a SCI. Twelve subacute, incomplete SCI (iSCI) subjects (ASIA C and D) were randomized in a trial with a double-blind, crossover design to receive 6 weeks of L-Dopa (200 mg), followed by 6 weeks of placebo, or vice versa. Outcome measures were ASIA Motor-Score (AMS) reflecting motor recovery; walking ability, assessed by the Walking Index of Spinal Cord Injury (WISCI); and Activities of Daily Living (ADL), as monitored by the Spinal Cord Independence Measure (SCIM). Both placebo and L-Dopa, in combination with physiotherapy, produced a significant motor recovery after SCI. The combination of L-Dopa and physiotherapy had no greater effect on the outcome than placebo and physiotherapy. The possible reasons for the different effect of L-Dopa in stroke and iSCI subjects are discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08977151
- Volume :
- 25
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Neurotrauma
- Publication Type :
- Academic Journal
- Accession number :
- 35733090
- Full Text :
- https://doi.org/10.1089/neu.2008.0583