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SigF Controls Carotenoid Pigment Production and Affects Transformation Efficiency and Hydrogen Peroxide Sensitivity in Mycobacterium smegmatis.
- Source :
-
Journal of Bacteriology . Dec2008, Vol. 190 Issue 23, p7859-7863. 5p. - Publication Year :
- 2008
-
Abstract
- Carotenoids are complex lipids that are known for acting against photodynamic injury and free radicals. We demonstrate here that σF is required for carotenoid pigment production in Mycobacterium smegmatis. We further show that a sigF mutant exhibits a transformation efficiency 104-fold higher than that of the parental strain, suggesting that σF regulates the production of components affecting cell wall permeability. In addition, a sigF mutant showed an increased sensitivity to hydrogen peroxide. An in silico search of the M. smegmatis genome identified a number of SigF consensus sites, including sites upstream of the carotenoid synthesis locus, which explains its SigF regulation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MYCOBACTERIUM
*HYDROGEN peroxide
*GENOMES
*CELLS
*CAROTENOIDS
*GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 00219193
- Volume :
- 190
- Issue :
- 23
- Database :
- Academic Search Index
- Journal :
- Journal of Bacteriology
- Publication Type :
- Academic Journal
- Accession number :
- 35569074
- Full Text :
- https://doi.org/10.1128/JB.00714-08