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Myelin proteolipid protein: An effective autoantigen and target of autoimmunity in multiple sclerosis
- Source :
-
Journal of Autoimmunity . Nov2008, Vol. 31 Issue 3, p281-287. 7p. - Publication Year :
- 2008
-
Abstract
- Abstract: Myelin proteolipid protein (PLP) is the most abundant protein in central nervous system (CNS) myelin and plays a major role in maintaining the structural and functional integrity of myelin. Its abundance in, and restriction to, CNS myelin and its post-translational modification by acylation make PLP an effective autoantigen, which can induce experimental autoimmune encephalomyelitis in rodents and non-human primates and which is a target of pathogenic autoimmunity in people with multiple sclerosis, a chronic inflammatory demyelinating CNS disease. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08968411
- Volume :
- 31
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 35393161
- Full Text :
- https://doi.org/10.1016/j.jaut.2008.04.018