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No association of TDP-43 with sporadic frontotemporal dementia
- Source :
-
Neurobiology of Aging . Jan2009, Vol. 30 Issue 1, p157-159. 3p. - Publication Year :
- 2009
-
Abstract
- Abstract: A hyperphosphorylated, ubiquitinated form of TDP-43, known as pathologic TDP-43, was shown to be a central component of ubiquitin-positive, tau-negative and alpha-synuclein-negative inclusions in frontotemporal lobar degeneration (FTLD-U) and amytrophic lateral sclerosis (ALS). To investigate the role of the TDP-43 gene in sporadic forms of frontotemporal dementia (FTD), we genotyped 10 single nucleotide polymorphisms covering the entire TDP-43 genomic region, including the MASP2 gene in 173 patients with sporadic FTD (including 7 patients that were diagnosed with FTD and ALS) and 184 matched controls from Germany. Although we could observe a weak trend towards a potential disease association in a few FTD/ALS patients, no significant association with sporadic FTD could be demonstrated. There is no evidence, that common variants in TDP-43 confer a strong risk to the development of sporadic FTD. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01974580
- Volume :
- 30
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Neurobiology of Aging
- Publication Type :
- Academic Journal
- Accession number :
- 35324632
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2007.05.022