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Diagnostic accuracy, reproducibility and robustness of fibrosis blood tests in chronic hepatitis C: A meta-analysis with individual data
- Source :
-
Clinical Biochemistry . Nov2008, Vol. 41 Issue 16/17, p1368-1376. 9p. - Publication Year :
- 2008
-
Abstract
- Abstract: Objectives: To evaluate the diagnostic accuracy of liver fibrosis tests and its influencing factors in a meta-analysis with individual data. Design and methods: Four independent centers provided four blood tests and Metavir staging from 825 patients with chronic hepatitis C. Results: FibroMeter AUROC (0.840) for significant fibrosis was superior to those of Fibrotest (0.803, p =0.049), APRI (0.789, p =0.001) and Hepascore (0.781, p <0.001). The misclassification rate was lower for FibroMeter (23%) than for Fibrotest and Hepascore (both 28%, p <0.001). The variation in the diagnostic cut-offs of tests among centers, reflecting the overall reproducibility, was: FibroMeter: 4.2%, APRI: 24.0%, Fibrotest: 24.2%, Hepascore: 35.0%. Accordingly, the proportion of patients diagnosed with significant fibrosis changed: FibroMeter: 0.8%, Hepascore: 2.4% (p =0.02 vs FibroMeter), Fibrotest: 5.8% (p <10−3), APRI: 18.2% (p <10−3). Conclusions: This study on clinical applicability shows significant differences in diagnostic accuracy, inter-center reproducibility, and robustness of biomarkers to changes in population characteristics between blood tests. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00099120
- Volume :
- 41
- Issue :
- 16/17
- Database :
- Academic Search Index
- Journal :
- Clinical Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 35073862
- Full Text :
- https://doi.org/10.1016/j.clinbiochem.2008.06.020