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Antioxidant activity of N-carboxymethyl chitosan oligosaccharides

Authors :
Sun, Tao
Yao, Qian
Zhou, Dongxiang
Mao, Fang
Source :
Bioorganic & Medicinal Chemistry Letters. Nov2008, Vol. 18 Issue 21, p5774-5776. 3p.
Publication Year :
2008

Abstract

Abstract: Three N-carboxymethyl chitosan oligosaccharides (N-CMCOSs) with different degrees of substitution (NA: 0.28, NB: 0.41, and NC: 0.54, respectively) were prepared by the control of the amount of glyoxylic acid in the etherification process of chitosan oligosaccharide (COS). Their antioxidant activities were evaluated by the scavenging of 1,1-diphenyl-2-picrylhrazyl radical (DPPH) radical, superoxide anion and determination of reducing power. With the increasing of substituting degree, the scavenging activity of N-CMCOSs against DPPH radical decreased and reducing power increased. As for superoxide anion scavenging, the order is NB>NC>NA. The difference may be related to the different radical scavenging mechanisms and donating effect of substituting carboxymethyl group. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0960894X
Volume :
18
Issue :
21
Database :
Academic Search Index
Journal :
Bioorganic & Medicinal Chemistry Letters
Publication Type :
Academic Journal
Accession number :
34892686
Full Text :
https://doi.org/10.1016/j.bmcl.2008.09.072