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Antioxidant activity of N-carboxymethyl chitosan oligosaccharides
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Nov2008, Vol. 18 Issue 21, p5774-5776. 3p. - Publication Year :
- 2008
-
Abstract
- Abstract: Three N-carboxymethyl chitosan oligosaccharides (N-CMCOSs) with different degrees of substitution (NA: 0.28, NB: 0.41, and NC: 0.54, respectively) were prepared by the control of the amount of glyoxylic acid in the etherification process of chitosan oligosaccharide (COS). Their antioxidant activities were evaluated by the scavenging of 1,1-diphenyl-2-picrylhrazyl radical (DPPH) radical, superoxide anion and determination of reducing power. With the increasing of substituting degree, the scavenging activity of N-CMCOSs against DPPH radical decreased and reducing power increased. As for superoxide anion scavenging, the order is NB>NC>NA. The difference may be related to the different radical scavenging mechanisms and donating effect of substituting carboxymethyl group. [Copyright &y& Elsevier]
- Subjects :
- *ANTIOXIDANTS
*CHITOSAN
*OLIGOSACCHARIDES
*ETHERIFICATION
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 34892686
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.09.072