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Controlled drug release from bifunctionalized mesoporous silica
- Source :
-
Journal of Solid State Chemistry . Oct2008, Vol. 181 Issue 10, p2837-2844. 8p. - Publication Year :
- 2008
-
Abstract
- Abstract: Serial of trimethylsilyl-carboxyl bifunctionalized SBA-15 (TMS/COOH/SBA-15) have been studied as carriers for controlled release of drug famotidine (Famo). To load Famo with large capacity, SBA-15 with high content of carboxyl groups was successfully synthesized by one-pot synthesis under the assistance of KCl. The mesostructure of carboxyl functionalized SBA-15 (COOH/SBA-15) could still be kept even though the content of carboxyl groups was up to 57.2%. Increasing carboxyl content could effectively enhance the loading capacity of Famo. Compared with pure SBA-15, into which Famo could be hardly adsorbed, the largest drug loading capacity of COOH/SBA-15 could achieve 396.9mg/g. The release of Famo from mesoporous silica was studied in simulated intestine fluid (SIF, pH=7.4). For COOH/SBA-15, the release rate of Famo decreased with narrowing pore size. After grafting TMS groups on the surface of COOH/SBA-15 with hexamethyldisilazane, the release of Famo was greatly delayed with the increasing content of TMS groups. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00224596
- Volume :
- 181
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of Solid State Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34870184
- Full Text :
- https://doi.org/10.1016/j.jssc.2008.07.011