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Incidence and predictors of delayed chronic kidney disease in long-term survivors of hematopoietic cell transplantation.
- Source :
-
Cancer (0008543X) . Oct2008, Vol. 113 Issue 7, p1580-1587. 8p. 3 Charts, 2 Graphs. - Publication Year :
- 2008
-
Abstract
- <bold>Background: </bold>The authors investigated the risk of delayed chronic kidney disease (CKD) in 1190 adult hematopoietic cell transplantation (HCT) survivors who underwent HCT for hematologic malignancies or aplastic anemia between 1976 and 1997 and survived for at least 1 year.<bold>Methods: </bold>CKD was defined as a sustained elevation of serum creatinine that indicated a glomerular filtration rate of <60 mL per minute per 1.73 m2 for > or =3 months. The median age at HCT was 35 years (range, 18.1-68.6 years), and the median length of follow-up was 7.1 years after HCT (range, 1-24.3 years).<bold>Results: </bold>Sixty patients with CKD were identified, resulting in a cumulative incidence of 4.4% at 5 years (autologous HCT, 3.8%; matched-sibling HCT, 4.5%; unrelated donor HCT, 10%; P = .09 compared with autologous HCT). Older age at HCT (relative risk [RR] per 5-year increment, 1.33; 95% confidence interval [CI], 1.2-1.5), exposure to cyclosporine without tacrolimus (RR, 1.90; 95% CI, 1.1-3.4) or with tacrolimus (RR, 4.59; 95% CI, 1.8-11.5), and a primary diagnosis of multiple myeloma (RR, 2.51; 95% CI, 1.1-5.6) were associated with an increased risk of delayed CKD.<bold>Conclusions: </bold>In this study, the authors identified a subpopulation of patients who underwent HCT and remained at increased risk for CKD. The current findings set the stage for appropriate long-term follow-up of vulnerable patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEMATOPOIETIC stem cell transplantation
*KIDNEY disease risk factors
*BLOOD diseases
*CYCLOSPORINE
*TACROLIMUS
*MULTIPLE myeloma diagnosis
*APLASTIC anemia treatment
*HEMATOLOGIC malignancies
*AUTOGRAFTS
*CHRONIC diseases
*COMPARATIVE studies
*HOMOGRAFTS
*KIDNEY diseases
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*EVALUATION research
*RELATIVE medical risk
*DISEASE incidence
*RETROSPECTIVE studies
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 0008543X
- Volume :
- 113
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Cancer (0008543X)
- Publication Type :
- Academic Journal
- Accession number :
- 34769823
- Full Text :
- https://doi.org/10.1002/cncr.23773