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Induction of follistatin precedes gastric transformation in gastrin deficient mice
- Source :
-
Biochemical & Biophysical Research Communications . Nov2008, Vol. 376 Issue 3, p573-577. 5p. - Publication Year :
- 2008
-
Abstract
- Abstract: We previously showed that antral gastric tumors develop in gastrin-deficient (Gas−/−) mice. Therefore Gas−/−mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation. Fundic atrophy developed by 9 months in Gas−/− mice. Antral mucosal hyperplasia developed coincident with the focal loss of TFF1 and Muc5AC. Microarray analysis of 12 month Gas−/− tumors revealed an increase in follistatin, an activin/BMP antagonist. We found that elevated follistatin expression occurred in the proliferative neck zone of hyperplastic antrums, in antral tumors of Gas−/− mice, and also in human gastric cancers. Follistatin induced cyclin D1 and the trefoil factors TFF1 and TFF2 in a gastric cancer cell line. We concluded that antral hyperplasia in Gas−/− mice involves amplification of mucous cell lineages due to follistatin, suggesting its role in the development of antral gastric tumors. [Copyright &y& Elsevier]
- Subjects :
- *RODENTS
*GASTROINTESTINAL hormones
*CHOLECYSTOKININ
*GASTRIC secretions
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 376
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 34748265
- Full Text :
- https://doi.org/10.1016/j.bbrc.2008.09.031