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Induction of follistatin precedes gastric transformation in gastrin deficient mice

Authors :
Kang, Weiqun
Saqui-Salces, Milena
Zavros, Yana
Merchant, Juanita L.
Source :
Biochemical & Biophysical Research Communications. Nov2008, Vol. 376 Issue 3, p573-577. 5p.
Publication Year :
2008

Abstract

Abstract: We previously showed that antral gastric tumors develop in gastrin-deficient (Gas−/−) mice. Therefore Gas−/−mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation. Fundic atrophy developed by 9 months in Gas−/− mice. Antral mucosal hyperplasia developed coincident with the focal loss of TFF1 and Muc5AC. Microarray analysis of 12 month Gas−/− tumors revealed an increase in follistatin, an activin/BMP antagonist. We found that elevated follistatin expression occurred in the proliferative neck zone of hyperplastic antrums, in antral tumors of Gas−/− mice, and also in human gastric cancers. Follistatin induced cyclin D1 and the trefoil factors TFF1 and TFF2 in a gastric cancer cell line. We concluded that antral hyperplasia in Gas−/− mice involves amplification of mucous cell lineages due to follistatin, suggesting its role in the development of antral gastric tumors. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0006291X
Volume :
376
Issue :
3
Database :
Academic Search Index
Journal :
Biochemical & Biophysical Research Communications
Publication Type :
Academic Journal
Accession number :
34748265
Full Text :
https://doi.org/10.1016/j.bbrc.2008.09.031