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‘Reverse’ α-ketoamide-based p38 MAP kinase inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Oct2008, Vol. 18 Issue 20, p5456-5459. 4p. - Publication Year :
- 2008
-
Abstract
- Abstract: We have identified a second series of potent p38 inhibitors. As with our first generation series, these compounds are based on an α-ketoamide scaffold. The reversal of the ketoamide order, however, introduces more chemical flexibility and in addition results in improve potencies against p38. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 34743537
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.09.028