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Isolation, structure elucidation, and mutagenicity of four alternariol derivatives produced by the mangrove endophytic fungus No. 2240.
- Source :
-
Chemistry of Natural Compounds . May2008, Vol. 44 Issue 3, p296-300. 5p. 1 Diagram, 2 Charts. - Publication Year :
- 2008
-
Abstract
- A new alternariol derivative, 2240B ( 1), together with alternariol ( 2), alternariol 4,10-dimethyl ether ( 3), and alternariol 4-methyl ether ( 4), was isolated from the ethyl acetate extract of the liquid medium GYT of No. 2240, the mangrove endophytic fungus from the South China Sea Coast. The structure of compound 1 was unambiguously elucidated as alternariol 4-methyl-10-acethyl ester by spectra including one/two-dimensional NMR, HREIMS, IR, and UV. The structures of compounds 2–4 were also established by spectroscopic analyses and comparison with related literature data. The anticancer tests showed that compounds 2 and 4 had strong activities against KB and KBv200 cells with IC50 values of 3.17, 3.12, and 4.82, 4.94 µg/mL, while compounds 1 and 3 exhibited weak activities against the two kinds of tumor lines with IC50 values of more than 50 µg/mL. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 44
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 34722880
- Full Text :
- https://doi.org/10.1007/s10600-008-9046-7