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The Kinetics of Hepatitis C Virus-Specific CD8 T-Cell Responses in the Blood Mirror Those in the Liver in Acute Hepatitis C Virus Infection.
- Source :
-
Journal of Virology . Oct2008, Vol. 82 Issue 19, p9782-9788. 7p. - Publication Year :
- 2008
-
Abstract
- Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the infection site. By studying serial liver and blood samples of five vaccinated and five mock-vaccinated control chimpanzees during acute HCV infection, we demonstrate a correlation between HCV-specific CD8 T-cell responses in the blood and molecular and functional markers of T-cell responses in the liver. Thus, HCV-specific CD8 T-cell responses in the blood are valid markers for intrahepatic T-cell activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATITIS C virus
*T cells
*VIRAL hepatitis
*LIVER diseases
*VACCINATION
*VIROLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 82
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 34640787
- Full Text :
- https://doi.org/10.1128/JVI.00475-08