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Interferon-alpha controls IL-17 expression in vitro and in vivo
Interferon-alpha controls IL-17 expression in vitro and in vivo
- Source :
-
Immunobiology . Nov2008, Vol. 213 Issue 9/10, p779-787. 9p. - Publication Year :
- 2008
-
Abstract
- Abstract: The type I interferons interferon alpha (IFNα) and IFNβ are the first line of defense potently induced upon viral infection, and at the same time are immunomodulatory cytokines bridging innate and adaptive immunity. T cells secreting interleukin-17 (IL-17) have recently been identified to regulate neutrophil-mediated inflammation, and have been implicated in the pathogenesis of experimental colitis and human inflammatory bowel disease, and are considered to regulate the inflammatory response in these models. We therefore hypothesized that type I IFNs as sentinels of viral infection might counteract the development of Th17 cells. We studied the effects of IFNα on IL-17 mRNA and protein expression in human peripheral blood mononuclear cells (PBMC) and during differentiation of human and murine naïve T cells into Th17 cells. In patients with ulcerative colitis (UC) treated systemically with IFNα, we studied colonic expression of IL-17 before and 4 weeks after therapy. IFNα potently suppressed IL-17 production in PBMC both at the mRNA and protein level. Th17 differentiation of human and murine naïve T cells was markedly suppressed in the presence of IFNα. UC patients exhibited increased IL-17 expression in colonic tissue biopsies compared to healthy controls, which was down-regulated during IFNα therapy. IL-17 expression in colonic tissue correlated with clinical remission in these patients. Our data suggest that IFNα down-regulates IL-17 expression and Th17 differentiation in vitro and in vivo. As a corollary, these effects might play a role in the mode of action of type I IFNs in the treatment of various diseases. [Copyright &y& Elsevier]
- Subjects :
- *ANTIVIRAL agents
*ANTI-infective agents
*DRUGS
*VIRUS inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 01712985
- Volume :
- 213
- Issue :
- 9/10
- Database :
- Academic Search Index
- Journal :
- Immunobiology
- Publication Type :
- Academic Journal
- Accession number :
- 34581456
- Full Text :
- https://doi.org/10.1016/j.imbio.2008.07.022