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A dynamic view of peptides and proteins in membranes.
- Source :
-
Cellular & Molecular Life Sciences . Oct2008, Vol. 65 Issue 19, p3028-3039. 12p. 2 Diagrams. - Publication Year :
- 2008
-
Abstract
- Biological membranes are highly dynamic supramolecular arrangements of lipids and proteins, which fulfill key cellular functions. Relatively few high-resolution membrane protein structures are known to date, although during recent years the structural databases have expanded at an accelerated pace. In some instances the structures of reaction intermediates provide a stroboscopic view on the conformational changes involved in protein function. Other biophysical approaches add dynamic aspects and allow one to investigate the interactions with the lipid bilayers. Membrane-active peptides fulfill many important functions in nature as they act as antimicrobials, channels, transporters or hormones, and their studies have much increased our understanding of polypeptide-membrane interactions. Interestingly several proteins have been identified that interact with the membrane as loose arrays of domains. Such conformations easily escape classical high-resolution structural analysis and the lessons learned from peptides may therefore be instructive for our understanding of the functioning of such membrane proteins. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEPTIDES
*BIOLOGICAL membranes
*MEMBRANE proteins
*LIPIDS
*POLYPEPTIDES
*PROTEINS
Subjects
Details
- Language :
- English
- ISSN :
- 1420682X
- Volume :
- 65
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Cellular & Molecular Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 34529722
- Full Text :
- https://doi.org/10.1007/s00018-008-8125-z