Pediatric standard-risk AML with fully matched sibling donors: to transplant in first CR or not?

Allogeneic hematopoietic SCT (HSCT) for children with standard-risk AML in first CR (CR1) is controversial. We reviewed 32 consecutive children with standard-risk AML who received matched sibling donor HSCT in CR1 from 1995 to 2004. With a median follow-up of 76 months (range: 36–114), 3 year EFS was 0.74 (95% confidence interval (CI): 0.57–0.88) and the overall survival was 0.81 (95% CI: 0.66–0.93). Only one patient died as a result of TRM. Larger studies, such as the MRC-UK 10 and 12, reported 60–62% EFS. Outcome of children with standard-risk AML transplanted from a matched sibling donor in CR1 is very encouraging with minimal toxicity.Bone Marrow Transplantation (2008) 42, 393–396; doi:10.1038/bmt.2008.182; published online 30 June 2008 [ABSTRACT FROM AUTHOR]