Synthesis, Characterization, and Electrochemical Studies on the Interaction of Binuclear Cu(II) Complex with DNA.

A new Schiff base ligand (KH2L) was synthesized using potassium salt of glycine and 2,4-dihydroxybenzaldehyde. A binuclear complex of this ligand [Cu2 (HL)2] 2H2O was synthesized and characterized by elemental analyses, IR, UV, TG-DTG, and molar conductance. The fundamental electrochemical characteristics of the Cu(II) complex have been studied, and the interaction of the copper complex and DNA was also studied by cyclic voltammetry and fluorescence spectra. The results of the cyclic voltammetry showed that the Cu(II) complex had an oxidation peak with the oxidation potential at -0.345 V. After the DNA was added, the peak current declined with the peak potential shifting positively. This suggested that the complex combined with DNA in the form of intercalative binding, which was also proved by the fluorescence analysis. [ABSTRACT FROM AUTHOR]