Leukocyte activation: The link between inflammation and coagulation during heatstroke. A study of patients during the 2003 heat wave in Paris.

The article reports on results of a study of the roles of the tissue factor pathway, leukocyte activation, and mediators of innate immunity in patients admitted to an intensive care unit for heatstroke during an intense heat wave in Paris, France . A description of the experimental set-up and measurement methods is provided. The study concluded that neutrophil activation plays a key role in the acute activation of coagulation observed during severe heatstroke.