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LFA-1 decreases the antigen dose for T cell activation in vivo.
- Source :
-
International Immunology . Sep2008, Vol. 20 Issue 9, p1119-1119. 1p. - Publication Year :
- 2008
-
Abstract
- Leukocyte adhesion molecule leukocyte function-associated antigen (LFA)-1 not only mediates intercellular binding but also delivers co-stimulatory signals in T cells. LFA-1 has been shown to decrease the threshold of TCR signal and an antigen dose required for T cell activation and proliferation in vitro. However, physiological significance of the role of LFA-1 in TCR signal has remained unclear. We examined whether LFA-1 decreased the antigen dose for T cell activation in vivo. We showed here that, although collagen-induced arthritis (CIA) could not be induced by immunization and challenge with a standard amount of type-II collagen in LFA-1-deficient mice, a higher dose of the antigen did induce CIA in the absence of LFA-1. We also showed that CD4+ T cells could be primed by immunization with a high, but not low, dose of ovalbumin antigen in LFA-1-deficient mice. These results suggest that LFA-1 decreases the threshold of TCR signal for T cell activation in vivo as well as in vitro. Further studies using TCR-transgenic LFA-1-deficient mice showed that LFA-1 cooperated with TCR in sustained Erk1/2 phosphorylation. Moreover, TCR could induce sustained Erk1/2 phosphorylation in the absence of LFA-1 when T cells were stimulated with a high, but not low, dose of antigen, suggesting that LFA-1 may cooperate with TCR in sustaining Erk1/2 phosphorylation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*LYMPHOCYTES
*PHOSPHORYLATION
*RODENTS
Subjects
Details
- Language :
- English
- ISSN :
- 09538178
- Volume :
- 20
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- International Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34034235
- Full Text :
- https://doi.org/10.1093/intimm/dxn070