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Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer
- Source :
-
European Journal of Cancer . Sep2008, Vol. 44 Issue 13, p1875-1882. 8p. - Publication Year :
- 2008
-
Abstract
- Abstract: We investigated the clinical significance of tumour-infiltrating FOXP3-positive regulatory T cells (Tregs) in radically resected (R0) gastric cancer. From a single-institution database, tumors of 110 patients who underwent R0 resection for stage II–III disease were studied for FOXP3-positive Tregs by immunohistochemistry. The observed median number of FOXP3-positive Tregs was used as the cut-point in analyses (<6 versus ⩾6 count). Tregs were significantly higher in gastric carcinomas than in normal tissue (P =0.0001). Tregs count ⩾6 was significantly associated with vascular/lymphatic/perineural invasion (VELIPI) in the tumour (P =0.03). Multivariate analysis showed association between adverse relapse-free survival and grading 3, stage III, VELIPI and Tregs count ⩾6 (P =0.02). Adverse overall survival was associated with grading 3, stage III, VELIPI and Tregs count ⩾6 (P =0.006). FOXP3-positive Tregs may be a novel marker for identifying high-risk gastric cancer patients. Present findings deserve additional investigation as Tregs may also represent an innovative therapeutic target. [Copyright &y& Elsevier]
- Subjects :
- *STOMACH cancer
*CANCER prognosis
*IMMUNOLOGY
*T cells
Subjects
Details
- Language :
- English
- ISSN :
- 09598049
- Volume :
- 44
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- European Journal of Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 33992793
- Full Text :
- https://doi.org/10.1016/j.ejca.2008.05.017