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CXCL6 (Granulocyte Chemotactic Protein-2): A Novel Chemokine Involved in the Innate Immune Response of the Amniotic Cavity.
- Source :
-
American Journal of Reproductive Immunology . Sep2008, Vol. 60 Issue 3, p246-257. 12p. 2 Charts, 2 Graphs. - Publication Year :
- 2008
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Abstract
- Problem CXCL6 is a potent pro-inflammatory neutrophil chemoattractant and activator whose activity during pregnancy is not well-established. The purpose of this study was to determine if CXCL6 is present in amniotic fluid (AF) and if CXCL6 concentrations in AF change with labor (pre-term and term) or intra-amniotic infection/inflammation (IAI). Method of study A cross-sectional study was designed including the following groups: (1) mid-trimester ( n = 65); (2) term no labor ( n = 20); (3) term labor ( n = 44); (4) patients with pre-term labor (PTL) with subsequent term delivery ( n = 57); (5) PTL without IAI who delivered pre-term ( n = 47); and (6) PTL with IAI ( n = 62). AF CXCL6 concentrations were determined by ELISA. Results CXCL6 was present in all term samples, but undetectable in 64/65 mid-trimester specimens. Patients with PTL and IAI had a significantly higher median AF CXCL6 concentration than those with PTL without IAI [228.9 pg/mL (0.0–8344.8) versus 55.7 pg/mL (0–454.4); P < 0.05] and those with PTL and term delivery [41.5 pg/mL (0–279.0); P < 0.05]. The median AF CXCL6 concentration did not change with spontaneous term labor [term no labor: 81.1 pg/mL (8.5–201.7) versus term labor: 75.2 pg/mL (6.7–378.7): P = 0.7]. Conclusion (1) CXCL6 is detectable in AF and its concentration increases with gestational age; (2) IAI results in increased AF CXCL6 concentrations, suggesting that CXCL6 plays a role in the deployment of an inflammatory response; (3) In contrast to related chemokines, specifically IL-8, AF CXCL6 does not appear to be involved in spontaneous term parturition. These observations are novel, and suggest a role for CXCL6 in the innate immune response to microbial invasion of the amniotic cavity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NEUTROPHILS
*CHEMOKINES
*AMNIOTIC liquid
*GRANULOCYTES
*PHAGOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 10467408
- Volume :
- 60
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- American Journal of Reproductive Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33864348
- Full Text :
- https://doi.org/10.1111/j.1600-0897.2008.00620.x