Regulation of the human Na+-glucose cotransporter gene, SGLT1, by HNF-1 and Sp1.

Describes the isolation and characterization of 5.3 kb of the 5'-flanking region of the Na+-glucose cotransporter (SGLT1) gene by transiently transfecting reporter constructs into a variety of epithelial cell lines. Identification of the human SGLT1 minimal promoter; Critical role of hepatocyte nuclear factor-1 and Sp1-multigene members.