THE PROMISE ON PHAGE DISPLAY: Customized Affinity and Specificity.

The article discusses phage display mechanisms and phage-based biosensors. Topics include the: advantages of using the bacteriophage called filamentous phage; manipulation of polypeptides on virus particle surfaces; selection of a polypeptide receptor and affinity screening; methods for immobilizing filamentous phage on biosensor surfaces; antibody binding on a covalent virus surface; prostate-specific membrane antigen--a cancer biomarker; biosensor transducer--electrochemical impedance spectroscopy; and binding of target molecules to macroscopic gold electrodes.