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Prognostic value of circulating CD34+ cells in myelodysplastic syndromes
- Source :
-
Leukemia Research . Nov2008, Vol. 32 Issue 11, p1715-1723. 9p. - Publication Year :
- 2008
-
Abstract
- Abstract: We studied circulating (C)CD34+ cells by flow cytometry in 96 patients with myelodisplastic syndromes (MDS) at diagnosis, and in a subset of 35 cases during follow-up. CCD34+ counts were stratified within both International Prognostic Scoring System (IPSS) and World Health Organization (WHO) categories. Counts >10/μl were associated with poorer leukemia-free survival, a prognostic value for evolution independent from that of WHO, and a higher progression probability within intermediate-risk IPSS and WHO classes. When serial measurements were performed, counts >10/μl more frequently correlated to evolution. Separating newly diagnosed patients on the basis of 10/μl cut-off of circulating CD34+ cells retains prognostic utility, especially in intermediate-risk MDS. [Copyright &y& Elsevier]
- Subjects :
- *MYELODYSPLASTIC syndromes
*DYSPLASIA
*BONE marrow diseases
*CELLS
Subjects
Details
- Language :
- English
- ISSN :
- 01452126
- Volume :
- 32
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Leukemia Research
- Publication Type :
- Academic Journal
- Accession number :
- 33344169
- Full Text :
- https://doi.org/10.1016/j.leukres.2008.03.028