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Protein Synthesis by Solid-Phase Chemical Ligation Using a Safety Catch Linker.
- Source :
-
Journal of Organic Chemistry . 06/16/2000, Vol. 65 Issue 12, p3829. 7p. 5 Diagrams, 7 Graphs. - Publication Year :
- 2000
-
Abstract
- Reports on the extensive use of the native chemical ligation reaction for the synthesis of the large polypeptides that correspond to folded proteins and domains. Dependence of the efficiency of the synthesis of the target protein on the number of peptide segments in the synthesis; Need for repeated purification and lyophilization steps.
- Subjects :
- *PEPTIDE synthesis
*PROTEIN synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 00223263
- Volume :
- 65
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 3327844
- Full Text :
- https://doi.org/10.1021/jo000346s