Asymmetric Total Synthesis of Botcinins C, D, and F.

Stereoselective total synthesis of botcinins C, D, and F is effectively carried out through asymmetric aldol reactions, 6- endoring closure, and SmI 2-mediated 3,4- transor - cisstereoselective intramolecular Reformatsky reaction. Rapid esterification of the main skeleton of botcinins with the chiral side chain using MNBA and DMAP produced botcinin D, an antifungal chemical against a pathogen of rice blast disease. [ABSTRACT FROM AUTHOR]