Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy.

Authors :: Heiser, Volker
Scherzinger, Eberhard
Source :: Proceedings of the National Academy of Sciences of the United States of America. 06/06/2000, Vol. 97 Issue 12, p6739. 6p. 7 Graphs.
Publication Year :: 2000
Abstract: Deals with a study which reported that the antibody 1C2 and the chemical compounds Congo red, thioflavine S, chrysamine G and Direct fast yellow suppress the in vitro aggregation of Huntington's disease (HD) exon 1 protein. Inhibition of Huntington fibrillogenesis by antibodies; Inhibition of Huntingtin aggregation by small molecules and cell culture systems.

Subjects :: *IMMUNOGLOBULINS
*CONGO red (Staining dye)
*HUNTINGTON disease
*BIOCHEMICAL mechanism of action

Language :: English
ISSN :: 00278424
Volume :: 97
Issue :: 12
Database :: Academic Search Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 3310089
Full Text :: https://doi.org/10.1073/pnas.110138997

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