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Carbon-carbon bond-forming reactions using alkyl fluorides.
- Source :
-
Pure & Applied Chemistry . May2008, Vol. 80 Issue 5, p941-951. 11p. - Publication Year :
- 2008
-
Abstract
- Paper based on a presentation at the 14th International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS-14), 2-6 August 2007, Nara, Japan. Other presentations are published in this issue, pp. 807-1194This account reviews C-C bond formation reactions using alkyl fluorides mostly focusing on the transition-metal-catalyzed reactions. These reactions proceed efficiently under mild conditions by the combined use of Grignard reagents and transition-metal catalysts, such as Ni, Cu, and Zr. It is proposed that ate complex intermediates formed by the reaction of these transition metals with Grignard reagents play important roles as the active catalytic species. Organoaluminun reagents react directly with alkyl fluorides in nonpolar solvents at room temperature to form C-C bonds. These studies demonstrate the practical usefulness of alkyl fluorides in C-C bond formation reactions and provide a promising method for the construction of carbon frameworks employing alkyl fluorides. The scope and limitations, as well as reaction pathways, are discussed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CONFERENCES & conventions
*CATALYSTS
Subjects
Details
- Language :
- English
- ISSN :
- 00334545
- Volume :
- 80
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Pure & Applied Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 33004270
- Full Text :
- https://doi.org/10.1351/pac200880050941