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Investigation of the interaction between acidic, basic, neutral, and zwitterionic drugs with poly- L-lactic acid by thermal and analytical methods.
- Source :
-
Journal of Thermal Analysis & Calorimetry . Jul2008, Vol. 93 Issue 1, p289-294. 6p. 1 Diagram, 2 Charts, 5 Graphs. - Publication Year :
- 2008
-
Abstract
- This project investigated the interaction between poly- L-lactic acid (PLLA) and several therapeutic agents. Low percentage crystallinity PLLA (melt-pressed, molded and drawn) was studied. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) were used to characterize the crystallinity and thermal properties in a thermal cycling process. Repeatable melting and crystallization events were observed. The thermal properties of a drug-polymer combination using PLLA and an acidic, basic, neutral and zwitterionic material were investigated. A sufficient quantity of the drug must be present in the polymer to be observed thermally. Release of atropine sulfate from a PLLA tablet showed a two-phase process. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13886150
- Volume :
- 93
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Thermal Analysis & Calorimetry
- Publication Type :
- Academic Journal
- Accession number :
- 32852895
- Full Text :
- https://doi.org/10.1007/s10973-007-8836-7