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The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.
- Source :
-
Nature Neuroscience . Jul2008, Vol. 11 Issue 7, p752-753. 2p. 2 Graphs. - Publication Year :
- 2008
-
Abstract
- We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GHRELIN
*APPETITE stimulants
*PSYCHOLOGICAL stress
*MENTAL depression
*SOMATOTROPIN
Subjects
Details
- Language :
- English
- ISSN :
- 10976256
- Volume :
- 11
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Nature Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 32756746
- Full Text :
- https://doi.org/10.1038/nn.2139