A rationally designed cocatalyst for the Morita–Baylis–Hillman reaction

Authors :: Jones, Charlotte E.S.
Turega, Simon M.
Clarke, Matthew L.
Philp, Douglas
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jul2008, Vol. 49 Issue 31, p4666-4669. 4p.
Publication Year :: 2008
Abstract: Abstract: The application of electronic structure calculations to a key transition state in the reaction manifold of the Morita–Baylis–Hillman reaction allows the design of two bis(thiourea) cocatalysts capable of accelerating this reaction through the hydrogen bond mediated recognition of both the nucleophile and the electrophile. [Copyright &y& Elsevier]

Subjects :: *UREA
*NITROGEN excretion
*CHEMICAL reactions
*HYDROGEN bonding
*ELECTROPHILES

Language :: English
ISSN :: 00404039
Volume :: 49
Issue :: 31
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 32731651
Full Text :: https://doi.org/10.1016/j.tetlet.2008.05.037