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Age-Related Changes in Endothelin-1 Receptor Subtypes in Rat Heart.
- Source :
-
Experimental Aging Research . Jul-Sep2008, Vol. 34 Issue 3, p251-266. 16p. 1 Chart, 3 Graphs. - Publication Year :
- 2008
-
Abstract
- Density, affinity, and subtype distribution of endothelin-1 (ET-1) binding sites were determined in rat cardiac tissue as a function of age in order to evaluate the association of alterations in the endothelin receptor system and aging in the heart. A significant decrease in the receptor subtype ET-A, which represents 70% to 80% of the total receptor population in cardiac tissue of 3- and 12-month-old rats, was observed in 24-month-old rats with respect to the younger groups. These findings indicate an alteration in ET-1 cardiac receptors associated with aging, mainly due to a variation in the receptor subtype distribution. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ENDOTHELINS
*BINDING sites
*BIOCHEMISTRY
*HEART
*LABORATORY rats
*TISSUES
Subjects
Details
- Language :
- English
- ISSN :
- 0361073X
- Volume :
- 34
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Experimental Aging Research
- Publication Type :
- Academic Journal
- Accession number :
- 32707743
- Full Text :
- https://doi.org/10.1080/03610730802070233