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Decreasing trends in methyldibromo glutaronitrile contact allergy – following regulatory intervention.
- Source :
-
Contact Dermatitis (01051873) . Jul2008, Vol. 59 Issue 1, p48-51. 4p. 2 Charts, 1 Graph. - Publication Year :
- 2008
-
Abstract
- Background: The preservative methyldibromo glutaronitrile (MDBGN) has been banned, first from stay-on, and later from rinse-off cosmetics, in the EU countries because of increasing rates of contact allergy. Objectives: To evaluate the frequency of contact allergy to MDBGN among patients patch tested by the Danish Contact Dermatitis Group just before and following regulatory decisions. Patients/Methods: The data set comprised 19 279 consecutive eczema patients patch tested from 2003–2007 with MDBGN 0.3% in petrolatum (pet.) or, in a minority of patients, with Euxyl K™ 400 1.5% in pet. Results: A significantly decreasing trend in the frequency of positive patch tests to MDBGN was found from 4.6% in 2003 to 2.6% in 2007 ( P < 0.001). The decreasing trend was seen for both men and women. A significantly decreasing proportion of cases with a current relevance of contact allergy to MDBGN was also seen from 51.3% in 2003 to 29% in 2007 ( P < 0.001). Conclusions: Regulatory interventions have already had a major effect on allergic disease due to MDBGN in Denmark. The same trends are likely to be seen in other EU countries. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01051873
- Volume :
- 59
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Contact Dermatitis (01051873)
- Publication Type :
- Academic Journal
- Accession number :
- 32659305
- Full Text :
- https://doi.org/10.1111/j.1600-0536.2008.01364.x