Control of epithelial cell structure and developmental fate: lessons from Helicobacterpylori.

The article discusses a paper by T. Kwok and colleagues, which reveals the targeting of integrin-containing focal adhesion sites in the delivery of Helicobacter pylori's CagA virulence protein to epithelial cells. The authors argue that the researchers were able to show how metozoan regulatory networks can significantly be changed by the delivery of critical effector molecules to focal adhesions, with their findings of CagL and integrin-dependent CagA delivery and phosphorylation.