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Tx3-4 a toxin from the venom of spider Phoneutria nigriventer blocks calcium channels associated with exocytosis
- Source :
-
Neuroscience Letters . Jul2008, Vol. 439 Issue 2, p170-172. 3p. - Publication Year :
- 2008
-
Abstract
- Abstract: The purpose of the present work was to investigate the pharmacological action of a calcium channel-blocking toxin from the venom of the spider Phonetic nigriventer, Tx3-4 on calcium channels coupled to exocytosis of synaptic vesicles. Tx3-4 blocked KCl-induced exocytosis of synaptic vesicles with an IC50 of 1.1nM. To investigate whether the target of Tx3-4 overlaps with known calcium channels that mediate calcium entry and exocytosis, we used ω-toxins that interact selectively with neuronal calcium channels. The results indicate that the main population of voltage-sensitive calcium channels altered by Tx3-4 is P/Q calcium channels. In conclusion, Tx3-4 is a potent inhibitor of calcium channels involved in the KCl-induced exocytosis of synaptic vesicles in brain cortical synaptosomes. [Copyright &y& Elsevier]
- Subjects :
- *SPIDER venom
*TOXINS
*CALCIUM channels
*EXOCYTOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 439
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 32558114
- Full Text :
- https://doi.org/10.1016/j.neulet.2008.05.019