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Antimicrobial activity of human beta-defensins and induction by Francisella
- Source :
-
Biochemical & Biophysical Research Communications . Jul2008, Vol. 371 Issue 4, p670-674. 5p. - Publication Year :
- 2008
-
Abstract
- Abstract: The ability of human beta-defensins hBD-1, hBD-2, and hBD-3 to exert direct in vitro antimicrobial effects was evaluated using Francisella tularensis Live Vaccine Strain (LVS) and Francisella novicida. While hBD-2 showed some antimicrobial activity in these assays, only hBD-3 demonstrated significant potency against Francisella. Francisella tularensis LVS infection induced elevated levels of hBD-2 mRNA in human airway epithelial (A549) cells, while having no significant impact on the levels of hBD-3 and only a moderate effect on the level of hBD-1 mRNA. Francisella infection avoided stimulating the production of the most potent anti-Francisella host peptide, hBD-3, in A549 cells, although hBD-3 is stimulated by other treatments. The differential induction of beta-defensins in Francisella infected lung epithelial cells suggests a complex dynamic in the expression of antimicrobial peptides and the innate immune response. [Copyright &y& Elsevier]
- Subjects :
- *MESSENGER RNA
*FRANCISELLA
*ANTI-infective agents
*VACCINES
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 371
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 32500961
- Full Text :
- https://doi.org/10.1016/j.bbrc.2008.04.092