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Anti-inflammatory activity of phylligenin, a lignan from the fruits of Forsythia koreana, and its cellular mechanism of action
- Source :
-
Journal of Ethnopharmacology . Jun2008, Vol. 118 Issue 1, p113-117. 5p. - Publication Year :
- 2008
-
Abstract
- Abstract: Aim of the study: The fruits of Forsythia koreana have long been used in Chinese medicine to treat inflammatory disorders. However, the pharmacological data is not sufficient to clearly establish a scientific rationale for the anti-inflammatory medicinal use of this plant material, and the search for its active principles has been limited so far. Materials and methods: Phylligenin (lignan) was isolated from the fruits of Forsythia koreana and its anti-inflammatory activity was examined. Results and conclusion: Phylligenin (1–100μM) and the methanol extract of Forsythia koreana fruits inhibited cyclooxygenase-2 (COX-2)-mediated prostaglandin E2 and inducible nitric oxide synthase (iNOS)-mediated nitric oxide (NO) synthesis from lipopolysaccharide-treated RAW 264.7 cells. In the mechanism study, phylligenin inhibited iNOS expression and nuclear factor-κB (NF-κB) activation but had no effect on COX-2 expression. Moreover, phylligenin significantly inhibited mouse carrageenan-induced paw edema by intraperitoneal administration (22.1–34.7% inhibition at 12.5–100mg/kg). These pharmacological properties indicate that phylligenin possesses significant anti-inflammatory activity in vitro and in vivo, and may provide the scientific rationale for anti-inflammatory use of the fruits of Forsythia koreana. [Copyright &y& Elsevier]
- Subjects :
- *ANTI-inflammatory agents
*LIGNANS
*FORSYTHIA
*CHINESE medicine
Subjects
Details
- Language :
- English
- ISSN :
- 03788741
- Volume :
- 118
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 32494906
- Full Text :
- https://doi.org/10.1016/j.jep.2008.03.016