Back to Search
Start Over
P2Y1 receptor antagonists as novel antithrombotic agents
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jun2008, Vol. 18 Issue 11, p3338-3343. 6p. - Publication Year :
- 2008
-
Abstract
- Abstract: The P2Y1 and P2Y12 purinergic receptors are responsible for mediating adenosine diphosphate (ADP) dependent platelet aggregation. Evidence from P2Y1 knockout studies as well as from nucleotide-based small molecule P2Y1 antagonists has suggested that the antagonism of this receptor may offer a novel and effective method for the treatment of thrombotic disorders. Herein, we report the identification and optimization of a series of non-nucleotide P2Y1 antagonists that are potent and orally bioavailable. [Copyright &y& Elsevier]
- Subjects :
- *ANTICOAGULANTS
*CARDIOVASCULAR diseases
*HEMATOLOGIC agents
*ADENOSINE diphosphate
Subjects
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 18
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 32494096
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.04.028