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P2Y1 receptor antagonists as novel antithrombotic agents

Authors :
Pfefferkorn, Jeffrey A.
Choi, Chulho
Winters, Thomas
Kennedy, Robert
Chi, Liguo
Perrin, Lisa A.
Lu, Gina
Ping, Yun-Wen
McClanahan, Tom
Schroeder, Richard
Leininger, Michael T.
Geyer, Andrew
Schefzick, Sabine
Atherton, James
Source :
Bioorganic & Medicinal Chemistry Letters. Jun2008, Vol. 18 Issue 11, p3338-3343. 6p.
Publication Year :
2008

Abstract

Abstract: The P2Y1 and P2Y12 purinergic receptors are responsible for mediating adenosine diphosphate (ADP) dependent platelet aggregation. Evidence from P2Y1 knockout studies as well as from nucleotide-based small molecule P2Y1 antagonists has suggested that the antagonism of this receptor may offer a novel and effective method for the treatment of thrombotic disorders. Herein, we report the identification and optimization of a series of non-nucleotide P2Y1 antagonists that are potent and orally bioavailable. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0960894X
Volume :
18
Issue :
11
Database :
Academic Search Index
Journal :
Bioorganic & Medicinal Chemistry Letters
Publication Type :
Academic Journal
Accession number :
32494096
Full Text :
https://doi.org/10.1016/j.bmcl.2008.04.028