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Pedunculopontine nucleus deep brain stimulation changes spinal cord excitability in Parkinson’s disease patients.
- Source :
-
Journal of Neural Transmission . May2008, Vol. 115 Issue 5, p731-735. 5p. 1 Chart, 1 Graph. - Publication Year :
- 2008
-
Abstract
- Bilateral peduncolopontine nucleus (PPN) and subthalamic nucleus (STN) deep brain stimulation (DBS) was performed in six-advanced Parkinson’s disease (PD) patients. We report the effect of both PPN-DBS (25 Hz) and STN-DBS (185 Hz) on patient spinal reflex excitability by utilizing the soleus-Hoffman reflex (HR) threshold. Compared to controls ( n = 9), patients showed an increase of HR-threshold, which was scarcely affected by levodopa, but significantly reduced by DBS. In particular, we found that PPN-DBS alone, or plus STN-DBS induced a complete recovery of HR-threshold up to control values. The HR-threshold changes, although do not allow to investigate the contribution of specific intraspinal pathways, suggest that PPN may play a key-role in modulating spinal excitability in PD possibly by improving the basal ganglia-brainstem descending system activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03009564
- Volume :
- 115
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Neural Transmission
- Publication Type :
- Academic Journal
- Accession number :
- 32466225
- Full Text :
- https://doi.org/10.1007/s00702-007-0001-8