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Cardiac sympathetic hypo-innervation in familial dysautonomia.
- Source :
-
Clinical Autonomic Research . Jun2008, Vol. 18 Issue 3, p115-119. 5p. 1 Color Photograph, 1 Graph. - Publication Year :
- 2008
-
Abstract
- Familial dysautonomia (FD) involves incomplete development of the sympathetic nervous system. Whether such loss extends to sympathetic innervation of the heart has been unknown. This study used 6-[18F]fluorodopamine neuroimaging to assess cardiac sympathetic innervation and function in FD. Six adult FD patients underwent thoracic PET scanning for 30 minutes after i.v. 6-[18F]fluorodopamine injection, as did healthy volunteers without ( N = 21) or with ( N = 10) pre-treatment by desipramine, which interferes with neuronal uptake and thereby simulates effects of noradrenergic denervation. Effective rate constants for uptake and loss were calculated using a single compartment pharmacokinetic model. FD patients had decreased uptake and accelerated loss of 6-[18F]fluorodopamine-derived radioactivity in the interventricular myocardial septum ( P = 0.009, P = 0.05) and ventricular free wall ( P = 0.007, P < 0.001), compared to untreated controls. Desipramine-treated subjects had decreased uptake but normal loss of 6-[18F]fluorodopamine-derived radioactivity. FD involves cardiac noradrenergic hypo-innervation. Since accelerated loss of 6-[18F]fluorodopamine-derived radioactivity cannot be explained by decreased neuronal uptake alone, FD may also involve augmented NE loss from extant terminals. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09599851
- Volume :
- 18
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Clinical Autonomic Research
- Publication Type :
- Academic Journal
- Accession number :
- 32466020
- Full Text :
- https://doi.org/10.1007/s10286-008-0464-1