L’aphasie progressive primaire : un cadre à part dans les pathologies neurodégénératives

Abstract: Introduction: Isolated progressive speech and language difficulties are often the first symptom of primary progressive aphasia. Exegesis: We report a 63-year-old woman with progressive language impairment that remained isolated for at least two years, related to a greater atrophy within the left hemisphere. There was no impairment in daily living during two years and six months. Progressively, she developed a frontal dementia. Conclusion: Isolated language impairment may be the inaugural symptom of a focal form of a neurodegenerative disease. Progressive language deterioration without impairment in daily life activity or behavioral changes must be differentiated from Alzheimer disease. Brain imaging is important for the diagnosis. [Copyright &y& Elsevier]