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Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis.
- Source :
-
Biochemistry & Cell Biology . Aug2007, Vol. 85 Issue 4, p477-483. 6p. 3 Diagrams. - Publication Year :
- 2007
-
Abstract
- Che-1/AATF (Che-1) was originally characterized as an interacting protein for RNA polymerase II. In addition to transcriptional regulation, the evidence suggests that Che-1 has a viral factor-like S phase promoting role in counteracting Rb repression to facilitate E2F-dependent transactivation during G1–S transition. Recently, Che-1 was found to play an important role in the DNA damage response and cell-cycle checkpoint control. Genetic studies in mice revealed that Che-1 is essential for preimplantation development and the establishment of embryonic gene expression. Importantly, several findings showed that Che-1 participates in inhibiting apoptotic process. Thus, Che-1 emerges as an important adaptor that connects transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08298211
- Volume :
- 85
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemistry & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 31959945
- Full Text :
- https://doi.org/10.1139/O07-062